منابع مشابه
Immunological pathogenesis of inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic inflammatory state of the gastrointestinal tract and can be classified into 2 main clinical phenomena: Crohn's disease (CD) and ulcerative colitis (UC). The pathogenesis of IBD, including CD and UC, involves the presence of pathogenic factors such as abnormal gut microbiota, immune response dysregulation, environmental changes, and gene variants. Al...
متن کاملInflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent research has suggested that genetic factors, environment, microbiota, and immune response are involved in the pathogenesis. Epidemiological evidence for a genetic contribution is defined: 15% of patients with Crohn...
متن کاملNeonatal Presentation of Unremitting Inflammatory Bowel Disease
Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian fe...
متن کاملPathogenesis of Inflammatory Bowel Diseases
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan Our understanding of IBD pathogenesis has been increasing rapidly. The genetically determined interplay between the commensal microbiota, intestinal epithelial cells, and the immune ...
متن کاملPathogenesis of Inflammatory Bowel Diseases
Ulcerative colitis (UC) and Crohn’s disease (CD), collectively called inflammatory bowel disease (IBD), are idiopathic, chronic, and relapsing intestinal inflammatory disorder, characterized by abdominal pain and diarrhea. UC differs dramatically from CD with the respects of disease distribution, morphology, and histopathology; for example, CD can affect any part of the gastrointestinal (GI) tr...
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ژورنال
عنوان ژورنال: Current Opinion in Gastroenterology
سال: 2012
ISSN: 0267-1379
DOI: 10.1097/mog.0b013e328353e61e